Selenium helps reduce bladder cancer risk

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New York: Increasing selenium levels may help to significantly reduce a woman’s risk of developing bladder cancer, according to new research from the American Association for Cancer Research

Researchers measured selenium levels in the toenails of 767 people with bladder cancer and 1,108 people without the disease. Whilst no link was found between selenium levels and bladder cancer risk for the population as a whole, the mineral did significantly reduce the risk of bladder cancer in certain groups of people – women, moderate smokers, and those with p53 positive cancer.

Lead researcher Margaret Karagas said: “Ultimately, if it is true that selenium can prevent a certain subset of individuals, like women, from developing bladder cancer, or prevent certain types of tumors, such as those evolving through the p53 pathway, from developing, it gives us clues about how the tumors could be prevented in the future and potentially lead to chemopreventive efforts.”

Vitamin B1protects against kidney disease

Recent study results suggest that taking a high-dose vitamin B1 supplement each day may help diabetics reduce their risk of kidney damage.

Diabetic nephropathy, or kidney disease, is a common complication of type 2 diabetes. An early indicator of kidney disease is microalbuminuria, where the kidney leaks albumin into the urine.

New research examined whether vitamin B1 would effect microalbuminuria and the results sugest it can reverse the onset of early diabetic kidney disease.

In the trial type 2 diabetics were given 300 milligrams of vitamin B1 (thiamine) each day for three months. Results showed that the vitamin supplement reduced the rate of albumin excretion by 41%. Furthermore, 35% of patients with microalbuminuria saw their urine albumin excretion return to normal after being treated with the vitamin.

The research is published online at Diabetologia

Early detection reduces oral cancer deaths – new study

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London: EXPERT studies have warned that late detection of mouth cancer is causing unnecessary deaths, backing the UK’s leading oral health charity’s Mouth Cancer Action Week 2008 campaign message.

A Journal of Prosthodontics study has called on greater emphasis on oral cancer screening. Early detection of oral cancer leads to a 95 per cent survival rate – yet currently the majority of cases are picked up late – with less than half surviving beyond five years.

The British Dental Health Foundation led the November’s Mouth Cancer Action Week with the call ‘If in doubt, get checked out.’

Foundation chief executive Dr Nigel Carter BDS LDS (RCS) said: “The majority of oral cancers are diagnosed at a late stage – which means so many deaths are unnecessary. Mouth cancer is often painless, this hidden killer causes a death every five hours in the UK.

“The public and the profession must all work together to make sure were stay aware of the dangers. Dentists and hygienists must communicate with their patients on this issue; while it is vital people visit their dentist regularly.”

Researchers at the Journal of Prosthodontics called for greater commitment from dentists to looking for mouth cancer: “If dentists are more vigilant in performing oral cancer screening examinations on all of their patients, the quality of life and survivability from these cancers will be greatly improved, whereby morbidity and mortality will be greatly reduced.”

The study urged use of screening aids to boost detection, and showed that the need for regular screenings had risen, as attempts to educate on prevention had stalled.

Nearly 5,000 people are diagnosed with oral cancer each year in the UK, with tobacco and alcohol related to around three quarters of all cases.

An ageing population puts more at risk in the most common over 40s age group, while increasing numbers of young are affected – a quarter of cases displaying no risk factors.

The human papilloma virus, transmitted through oral sex, has also been linked to rising numbers of mouth cancer incidences.

The Foundation’s 2008 mouth cancer survey showed one in five UK patients remain unaware of mouth cancer. Seventy per cent of patients said they had not discussed the disease with their dentist, and were not sure they had ever received oral screening.

Mouth Cancer Action Week 2008 was launched at the Houses of Parliament in November 2008, with a speech by leading expert Professor Saman Warnakulasuriya calling for government support for dentists giving oral screening.

The campaign highlighted a need for the public to self examine, looking out for ulcers that do not heal within three weeks, red and white patches in the mouth, and lumps, swelling or unusual changes in the mouth and neck.

Find more information at www.mouthcancer.org

Facts and Figures

In the UK over 4,750 are diagnosed each year.

Around 1,700 people die of mouth cancer every year.

Mouth cancer is more common in men than women, but the gap is closing

Mouth cancer is more likely to affect people over 40 years of age, though an
increasing number of young people are developing the condition.

Tobacco and alcohol are thought to contribute to 80 per cent of mouth cancer cases.

Smoking is the number one cause for mouth cancer. Cigarette smoke converts saliva into a deadly cell-damaging cocktail.

Switching to low-tar cigarettes will not help, as smokers of ‘lights’ tend to inhale more smoke than smokers of ‘regular’ cigarettes.

Although some people believe that chewing tobacco is safer than smoking, the reality is that it is even more dangerous. Chewing tobacco, paan, areca nut and gutkha are habits favoured by some ethnic groups.

Alcohol aids absorption of smoke into the mouth – people who smoke and drink alcohol to excess are 30 times more likely to develop mouth cancer.

Poor diet is linked to a third of all cancer cases. Evidence shows an increase in fruit and vegetables lowers the risk, as can fish and eggs.It is recommended that people enjoy a healthy, balanced diet, including food from each of the major food groups and including fruit and vegetables of all different colours as each colour contains different vitamins

Research now suggests the human papilloma virus (HPV) – transmitted by oral sex – could soon rival smoking and drinking as a main cause of mouth cancer.

Early detection and treatment considerably increases survival chances, allows for simpler treatment and results in a better quality of life for sufferers

The Charity

The British Dental Health Foundation is the UK’s leading oral health charity, with a 30-year track record of providing public information and influencing government policy. It maintains a free consumer advice service, an impartial and objective product accreditation scheme, publishes and distributes a wide range of literature for the profession and consumers.

National Smile Month runs each May, to promote greater awareness of the benefits of better oral health, with Mouth Cancer Action Week each November.

The Dental Helpline, which offers free impartial dental advice to consumers, can be contacted on 0845 063 1188 between 9am and 5pm, Monday to Friday or by e- mailing helpline@dentalhealth.org.uk

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Cognitive Behavioural Therapists UK

A NEW on-line register, CBT Register UK gioves the public access to all accredited Cognitive Behavioural Therapy (CBT) practitioners in the UK.

As the leading organisations in the CBT field, the British Association for Behavioural and Cognitive Psychotherapies (BABCP) and the Association for Rational and Emotive Behaviour Therapy (AREBT) have been accrediting CBT therapists since 1994.

In line with government moves to improve access to effective psychological therapies, the two organisations have now come together to form a single CBT Register UK.

It means members of the public who are looking for an accredited CBT therapist will be able to find one within just a few clicks.

More than 1,400 therapists, who are working within the NHS, private practice, or both, are accredited on the new CBT Register UK. This means they have specialist skills and knowledge, having undergone training and supervision to recognised standards.

There has been an increasing demand from the public, health professionals and health care providers for a register which lists fully qualified therapists who have achieved a high level of competence in cognitive and behavioural methods.

BABCP and AREBT say it is vital that members of the public are able to easily and quickly find an accredited Cognitive Behavioural Therapist on-line. The new joint CBT Register UK, with easy to access information, is an essential aid for those seeking CBT for emotional problems or a range of mental health conditions.

CBT, which is supported by extensive clinical research, is recommended as an effective treatment for a range of mental health conditions by NICE (the National Institute for Health and Clinical Excellence).

“This is the first and only definitive and complete register of accredited CBT and AREBT therapists in the country,” said BABCP President, Professor John Taylor.

“Members of the public who are looking for a CBT therapist will be able to go straight to the CBT Register UK which is a specially dedicated website. It is a web-based, one-stop shop for talking therapists.”

“We believe the register will make CBT much more widely available to more people.” said AREBT Chair, Irene Tubbs

“The CBT Register UK gives the public easy access to highly trained and fully qualified therapists, ensuring quality provision.”

More information

1. Together the BABCP and AREBT now have over 7,000 members, including
psychologists, psychiatrists, counsellors, social workers, occupational
therapists, and mental health nurses.

2. The Government recently announced a £173 million Improving Access to
Psychological Therapies (IAPT) programme to improve access on the NHS
to effective talking therapies such as CBT for anxiety and depression
through a series of centres all over the country.

Exercise helps prevent brain shrinkage

New research in Alzheimer’s prevention shows the important relationship between exercise and preventing Alzheimer’s disease.

A new study has found that people with early Alzheimer’s disease who were less physically fit had four times more brain shrinkage than those who were more physically fit.

(Researchers think that exercise has a direct effect on preserving brain volume, says lead author Jeffrey M. Burns, MD. Preserving brain volume also aids brain function.

“People with early Alzheimer’s disease may be able to preserve their brain function for a longer period of time by exercising regularly and potentially reducing the amount of brain volume lost,” Dr. Burns writes. “Evidence shows decreasing brain volume is tied to poorer cognitive performance, so preserving more brain volume may translate into better cognitive performance.”

The people were tested with treadmill walking, oxygen consumption (a measure of aerobic fitness), mental tests and brain imaging. The results strongly indicated the positive benefits of exercise and a correlation with the prevention of Alzheimer’s disease.

Exercise isn’t the only thing that can help your brain resist the ravages of this disease. There are many proven natural ways to prevent Alzheimer’s. Research supports the use of fish oil, ginkgo, vitamin D, vitamin E, folic acid, green tea and curcumin as effective steps towards Alzheimer’s prevention.

Numbers of “oldest old” set to double in 25 years – UK report

London: The ageing population in the UK is growing rapidly, according to new Government statistics.

Nearly one in four of the population will be over 65 in less than 25 years, and the number of those over 85 – the “oldest old”, would more than double.

The forecast from the Office for National Statistics says this will result more resources being directed towards the elderly including health and social care and transport.

Improvements in medical treatments and social conditiions mean that many more people are living longer and the younger generation will have to work longer and pay more in taxes.

The ONS said that the number of people expected to live more than 85 years would rise to more than three million by 2032. It added that the number of people with dementia could double to 1.4 million within 30 years.

By 2032 the 85-plus group will make up 4 per cent of the population. That means the proportion of people who use public services the most and who depend on family, neighbours and so on is increasing.

The report also said that increasing the retirement age was the key to supporting the millions of extra older people who will need assistance.

But increasingly men and women will face the dilemma of how to look after their elderly relatives when they themselves are reaching retirement.

Demand for long-term care is inevitably going to increase over the coming years as the population aged 85 and over grows.

The new figures show there were 9.5 million over 65s in 2007. By 2032 the figure is projected to increase to 16.1 million, 23 per cent of the estimated total population.

In 1982 there were 600,000 people over 85, or 1.1 per cent of the total population. By last year this had doubled to 1.3 million and will rise to 3.1 million by 2032.

In spite of the growing number of old people, the proportion of over 65s living in communal establishments fell between 1991 and 2001 as a result of government policies to support people in their own homes and communities.

The analysis also showed that men are living longer and closing the gap with women.

Flu spreads the commuter transport system

London: One sneeze from a rush-hour commuter can end up giving up to 150 fellow passengers a cold in just five minutes, researchers have found.

Unless they are contained in a tissue or handkerchief, the germs spread so quickly that within seconds they are being passed on via handrails on escalators or seats on trains and even on discarded newspapers, revealed the study.

Each sneeze contains around 100,000 droplets at a speed of 90 mph.

The researchers surveyed 1,300 workers, on behalf of flu drink Lemsip, about their health and found almost all commuters suffered at least one cold last winter.

The results were analysed by cold and flu expert Dr Roger Henderson, who looked at the daily commute of the sneeze itself.

Up to 10 per cent of all commuters will come into contact with an area infected by that one sneeze, Dr Henderson calculated.

In the busiest areas, such as escalators at stations, this amounts to around 150 people during rush hour, he said.

The research found that in contrast, only 58 per cent of those who work from home regularly caught a cold last winter.

This compares with 99 per cent who travel by Tube, 98 per cent who go by bus and 96 per cent of train passengers. But it falls to 88 per cent of those who walk to and from work, according to the survey.

A new survey says up to 10 per cent of all commuters will come into contact with sneeze-infected areas

They found 20 per cent are annoyed by fellow travellers sneezing without using a tissue and 33 per cent are angered by those who cough without covering their mouths.
Men are more likely to be at fault – one in three do not carry a tissue compared with 81 per cent of women.

Relentless sniffing gets on the nerves of 12 per cent of travellers, although throat-clearing is only an issue for three per cent.

But most will either walk away or grin and bear it. Only eight per cent will actually say anything to an annoying sneezer or cougher sitting next to them.

Perhaps they realise they are just as guilty as two thirds (67 per cent) admit to travelling in to work even when they are feeling ill.

The company is offering cold and flue advice which includes stocking up on tissues and not leaving old newspapers behind.

The end of hair armpits rollon

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London: Two new deodrants which claim to slow down the speed of hair growth are to be launched near year.

The Sure and Dove Hair Minimising roll-ons and sprays, both manufactured by Unilever, are expected to appeal to young women and promise results within a month of use.

Their underarm hair should be less noticeable, finer and easier to remove. However, hair growth will quickly return to normal if they stop using the deodorant.

Sian Jenkins of Dove said: “Consumer testing has shown that women notice a difference to their underarms after just a few weeks – shaving time off their normal regime.”

Unilever scientists have spent three years developing the new formula and is based on a ‘pro-epil’ complex-which is said to slow the rate of hair growth.

The deodorants should be used only in the underarm area, he added.

The new deodrants appeal to the modern day dislike of hairy armpits on women. Women sporting the natural look are a non-conformist.
Julia Roberts discovered just how much society frowns on armpit fuzz when she displayed her hairy underarms at the London premiere of her film Notting Hill in 1999.
The actress, who is thought to have cultivated the look to please her boyfriend of the time, said later: “You’d think it was a chinchilla I had under there the way the world responded.”

Women witth fatter tums better able to deal with stress

Salt Lake City: Women who have extra fat around their middle may enjoy significant health advantages over slimmer hourglass-shaped females, says a 37-nation study in the journal, Current Anthropology.

Elizabeth Cashdan, a Utah University anthropologist, says that being thinner could mean missing out on the hormones that make women physically stronger, more competitive and better able to deal with stress.

Her study shows that across the world, women’s average waist-to-hip ratio is higher than the magic number of 0.7, the upper threshold of a classic hourglass figure – and the shape that anthropologists believe indicate female fertility to the opposite sex.

It is thought that bigger women have more androgens, a class of hormones that includes testosterone.Androgens increase the waist-to-hip ratio in women by boosting levels of visceral fat, which is carried around the waist. Raised levels of androgens are linked to increased strength, stamina and competitiveness in women, says Cashdan.

Trading the benefits of a thin waist for better ability to be independently resourceful may prove a good deal in many societies, she adds – and this in turn may alter male preferences.

Thus, in Japan, Portugal and Greece, where women tend to be less economically independent, the men say they place a higher value on a thin waist than do men in Britain or Denmark, where there tends to be more sexual equality.

And in some non-Western societies where food is scarce and women bear most of the responsibility for finding it, men prefer larger waist-to-hip ratios.

“Whether men prefer a waist-to-hip ratio associated with lower or higher androgen levels should depend on the degree to which they want their mates to be strong, tough, economically successful and politically competitive,” says Cashdan .

Norway’s oldest woman dies

Oslo: Norway’s oldest woman, Gunda Harangen, who had attributed her longevity to celibacy and her daily glass of cognac, has died at the age of 109.

Harangen, the eldest of seven children, was born on December 28, 1898.

In a 2006 interview on the secret of her longevity, she said she believed she had lived so long because she drank one glass of cognac every day and did not have a man in her life.

She passed away in her sleep on November 25, her nephew told the local Laagendalsposten daily in south-eastern Norway.

Ageing biomarkers identified?

Medical experts move towards identifying “biomarkers” of ageing, according to a new study published by Ageing Cell.

If scientists are able identify such markers in humans, they suggest it could provide the means for the scientific validation of anti-ageing therapies.

“This is the first evidence that physiological age can be predicted non-subjectively,” said lead study author Simon Melov.

“We were able to predict the ages of the animals 70 per cent of the time, which is far better than anything … done before,” the scientist added.

Meanwhile another team of researchers suggests it has gained an insight into how some people appear able to maintain extremely sharp powers of memory despite being aged in their 80s or older.

The experts from the Feinburg School of Medicine said such individuals’ brains were found to contain far fewer fibre-like tangles than those of other people who had aged in a more typical fashion.

Stem cells used to grow frog eye

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New york: In an experiment at the SUNY Upstate Medical University, in Syracuse, NY researchers have grown frog eyes from stem cells.

Researcher Michael Zuber and his colleagues took the cells from frog eggs.Then got them to become eyes, by genetically modifying them, inserting transcription factors (proteins that trigger expression of other genes) which are known to regulate eye growth and development.

The scientists then implanted the cells into tadpoles missing an eye. The cells properly developed and differentiated into all seven types of retinal cells and appeared to have the proper structure. Additionally the new eye attached properly to the brain. In swimming tests the eye was shown to be working as implanted tadpoles only swam to the white side of the tank (normal behavior), while blind ones would also swim to the black side of the tank.

Would the technique work on mammals? The answer is maybe — frogs naturally have a much easier type regrowing tissues than humans, in fact they can be triggered to regrow legs and many amphibians can regrow lost tails. Triggering proper differentiation in mammals is much more complex.

Nonetheless, Professor Zuber hopes that chemicals will be found from the research that can activate transcription factors in humans. Even if a full eye could not be grown, this could help people with retinal disorders regenerate ocular tissue.

In a separate, but perhaps equally intriguing study performed by Sujeong Jang of Chonnam National University, in South Korea, and his colleagues, the researchers were able to restore the hearing of deaf guinea pigs by implanting them with human neural stem cells obtained from human bone marrow.

Scientists move closer to human immortality

Madrid: Scientists at the Spanish National Cancer Centre found evidence that a natural protein could be the key ingredient in an elixir of eternal youth.

According to the scientists, boosting the amount of the naturally forming substance, telomerase, in the body could prevent cells from dying and thereby slow the process of ageing.

Telomerase helps maintain the protective caps at ends of chromosomes which act like ends of shoelaces and stop them unravelling. As people age and the cells divide, these caps become frayed and shorter and are so damaged that the cell dies eventually.

So far the scientists have only carried out an experiment on laboratory rodents. They found that those mice genetically engineered to produce ten times the normal levels of telomerase lived 50 per cent longer than normal. Those animals also had less fat, had better co-ordination and were better at processing sugar.

Lead researcher Maria Blasco said that the enzyme was capable of turning “a normal, mortal cell into an immortal cell” and a similar approach could eventually lead to extended human lifespans.

“You can delay the ageing of mice and increase their lifespan. (But) I think it is very hard to extrapolate data from mouse ageing to human ageing,” she told the New Scientist magazine.

One of the problems with boosting telomerase is that it can increase the risk of cancer. However, she said that the obstacle could be overcome by issuing cancer drugs that could offset the negative affects.

Scientists grow windpipe to renew a woman’s life

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London: Scientists have used stem cells to grow part of a windpipe which was later implanted into a woman whose own trachea had been destroyed by tuberculosis.

The breakthrough procedure, which happened in Barcelona, Spain, is described in online in the British medical journal, The Lancet.

Claudia Castillo, 30, a mother of two living in Barcelona had been suffering from tuberculosis for years. The disease destroyed part of her trachea, the windpipe connected to the lungs. In March, her left lung collapsed and Castillo needed regular hospital visits to clear her airways which left her unable to take care of her children.

Doctors had planned to remove her entire left lung but instead, Dr. Paolo Macchiarini, head of thoracic surgery at Barcelona’s Hospital Clinic, proposed a windpipe transplant instead. He was the one performing the surgery on Castillo.

With the help of a new technique developed at the University of Padua, Italy, scientists removed all the cells from the trachea of a 51-year old donor by essentially scrubbing it clean with a high-tech detergent solution.

Meanwhile, doctors at the University of Bristol, in England took a sample of Castillo’s bone marrow from her hip. They used the bone marrow’s stem cells to create millions of cartilage and tissue cells to cover and line the windpipe. Then doctors at the University of Milan used a device to put the new cartilage and tissue onto the windpipe, which was transplanted into Castillo in June.

The surgery was a real success, the authors reported.

“Within four days after transplantation, the graft was almost indistinguishable from adjacent normal bronchi,” Dr. Macchiarini said. After a month, a biopsy of the site proved that the transplant had developed its own blood supply. Also there was no sign of rejection after four months.

“The possibility of avoiding the removal of my entire lung and, instead, replacing only my diseased bronchus with this tissue engineering process represented a unique chance for me to return to a normal life that I am now enjoying with my children and family,” Castillo said in a news release.

Now the doctors believe that “this first experience represents a milestone in medicine and hope that it will unlock the door for a safe and recipient-tailored transplantation of the airway in adults and children.”

However, Castillo needs to be closely monitored, as it can take up to three years to know if the windpipe’s cartilage structure s solid and won’t fall apart. She takes no drugs to suppress her immune system, a standard approach to prevent rejection when foreign donor organs are used in a transplant. She is able to walk 500 meters without stopping, climb stairs and take care of her children, Johan, 15, and Isabella, four.

US watchdog to review wrinkle-fillers

New York: US health watchdog, the Food & Drug Administration, is to investigate whether anti-wrinkle injections should have new warnings about potential side effects.

A panel of outside advisers to the FDA will meet this week to review reports of dermal filler side effects, and to consider whether the regulatory agency should place new warnings or instructions on the injections used to reduce wrinkles and scarring.

According to an FDA document posted Friday on the agency’s website, there have been 930 reports of dermal filler side effects received between 2003 and September 20, 2008. Some of the problems were associated with administration of the injections by untrained professionals or in a setting other than a doctor’s office.

Although no specific products were identified by the FDA, the more popular dermal fillers available include Restylane and Perlane from Medicis, Juvederm from Allergan Inc. and Radiesse from Bioform Medical.

Dermal fillers, which are also known as wrinkle fillers, are injections given to smooth wrinkles for a younger look or to reduce the appearance of scarring. According to the American Society for Aesthetic Plastic Surgery, about 84,000 men and 1.36 million women received a wrinkle filler injection in 2007.

The FDA advisory panel is scheduled to meet tomorrow in Washington, D.C. to review the safety of these products and whether any regulatory actions, such as strengthened warnings or additional instructions, may be necessary to protect the public.

The FDA review indicates that some people given dermal fillers suffered “serious and unexpected” side effects, such as facial palsy, disfigurement and rare life-threatening allergic reactions or anaphylactic shock. In some cases, surgical procedures have been required to treat these problems, such as draining abscesses.

Other wrinkle filler side effects have included inflammation, pain at the injection site, numbness, bleeding, blistering, bruising, migration, formation of lumps or nodules and infection. Minor problems, such as a small amount of swelling or redness, are known and expected side effects and are currently described in the product literature.

The FDA is attempting to determine whether additional studies are necessary and whether any updates should be made to the product labeling. Although the FDA is no required to follow the recommendations of their advisory committees, they often do.

Life expectancy in Britain falls

London: Britons have one of the lowest life expectancies in Europe, according to a new study published in the medical magazine, The Lancet.

Researchers at Leicester University discovered that a British woman who reached the age of 50 in 2005 can expect to live for another 32.7 years – reaching 82 years and eight months – ten months less than the European average.

This figure is lower than that for France and Germany, according to the league table of 25 European Union countries.

Britain came just 16th, just above the poorer nations of eastern Europe, and Denmark.

The figures also revealed that while British men’s relative position is slightly better than women’s, they still lag behind countries such as France.

A British man who reached 50 in 2005 – the most recent year for which figures are available – can expect another 29 and a half years of life.

This is about ten months above the European average, but a month lower than France and 11 months lower than Italy.

UK health warning over Barbie tan drug

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London: UK health watchdogs have joined the US in warning the public about the health dangers of an unlicensed injectable tanning drug, knicknamed the “Barbie Drug.”

The drug, which is known by the names Melanotan and Melanotan II is a synthetically-made hormone that stimulate the body to produce melanin, which gives the body a deep natural tan without the sun.

It is most popular with athletes and fitness enthusiasts who prefer not to expose themselves to sun damage.

As well as protection against burning, Melanotan, is also credited with boosting libido and an appetite depressant which hasled to it being nicknamed the ‘Barbie drug’ or ‘paradise pill’.

Despite its popularity, the American-made drug, has never been licensed for public use either in the US or Europe. But it continues to be sold illegally over the internet and in gyms and beauty salsons for up to £250.

In the UK the Medicine and Healthcare Regulatory Agency (MHRA) has issued a warning over the drug because not enough is known about the possible side-effects.

In addition, people injecting themselves run the risk of contracting HIV or other viruses from dirty needles.

David Carter, head of the MHRA unit for ‘borderline’ drugs, said people should not be fooled into thinking it was safer than the sun and warned anyone who had them not to use them again. Anyone who has used them should see a doctor, he said.

“The safety of these products is unknown and they are unlicensed in the UK. The side effects could be extremely serious,” he said.

Japanese scientists create brain tissue

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Tokyo: Japanese researchers have succeeded in creating a cerebral cortex, the part of the brain involved in thinking and motion, from embryonic stem cells, giving hope for future treatment of brain-related diseases.

The process using embryonic stem cells, which can change into various other types of cells, was successfully carried out by Yoshiki Sasai and Mototsugu Eiraku, of the Riken Center for Developmental Biology in Kobe.

The cortex remained undeveloped, equivalent to that of a fetus, but it’s the first time that researchers have ever created brain tissue involving different cell types, rather than single brain cells. The research is published in the US magazine Cell Stem Cell.

Researchers hope that the process will shed light on the how illnesses like Alzheimer’s disease work and how they can be cured, as well as leading to treatments to lessen the aftereffects of strokes.

The researchers placed about 3,000 embryonic stem cells in a culture solution, and had the cells gather together naturally to form a solid, and, after 46 days, a sphere of tissue measuring two millimeters in diameter, with a hollow at its center, was formed.

The self-organized tissue uses four types of neurons in four layers, and is identical to the cerebral cortex of a fetus seven to eight weeks after conception. The researchers confirmed that the neurons formed a network, and the cells were able to activate simultaneously.

An adult cerebral cortex has six layers. Accordingly, the stage of development of the cortex in the experiment could be presumed to be at about “40 or 50 percent,” according to Mr Sassi.

Exercise trial for arthritis pain

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Toronto : Certain types of exercise can help reduce the pain and symptoms of knee arthritis.

Now a $5million study of the benefits of exercise is looking to recruit Canadians with osteo-arthritic knee pain for further research to be carried out at the University of Calgary’s Sport Medicine Centre.

Andrew Marsh, a master’s student co-ordinating the active aspect of the study, says the project will further test the theory that exercise aids in the treatment of the condition.

The is being funded by the Alberta Heritage Fund for Medical Research, and is a free, supervised, three-month exercise program open to individuals over the age of 40. Those who are younger and living with osteoarthritic pain due to past surgeries may also qualify.

Over six per cent of Canadian adults over 30 experience osteoarthritis, and by age 65, that number jumps to 11 per cent.

Co-ordinators and specialists will follow the activity and personal experiences by participants, who must be committed to exercising over the 12 weeks, most of which can be conducted at home. No heavy weights are involved and everyone will receive the necessary training and equipment.

The exercises will focus on various areas of the lower body, including the hips and thighs, which lend support to knees.

Since osteoarthritis is a gradual progression with often subtle signs of pain or immobility, and key to reducing pain is to increase strength around the joint and within the core so the body is better able to move.

The potential for this study to branch out into other areas of health care is exciting and far reaching, adds Ferber.

“This is unique because we’re doing a whole body study and that’s ever been done before,” he says. “Once the results are published, the knowledge can then be used to help patients and inform physicians, and therapists.”

For more information about participating in the study, call + 1 403-220-3523 or e-mail kneeoa@ucalgary.ca

New pill can “jumpstart” youth hormone

New York: A new drug can boost levels of one of the most important “youth hormones” in older people, according to a new study by the University of Virginia.

Patients aged between 60 and 61, took doses of an experimental drug called MK-677, that prompts the body to release growth hormone, over a two-year period. This lead to them gaining lean fat-free muscle mass and a redistribution of “middle-age spread” to the arms and legs. There was also a decrease in insulin sensitivity.

Altogether the trial involved 65 healthy people, some of whom were given a placebo. Doctors found that patients who had received the therapy experienced an increase in growth hormone levels equivalent to levels seen among healthy young adults. The findings are reported in the Nov. 3 issue of the Annals of Internal Medicine.

This compared to those who didn’t get the growth-hormone boosting therapy losting about one pound of muscle in a year, wheras those who got the drug gained about two pounds of muscle mass

Growth hormone levels are highest during mid-puberty, but drop by about half by the time men and women turn 30. The decline continues , with levels diminishing at a rate of about 50 percent every 7 years.

Study author, Dr Michael Thorner said: “As we all get older, our body composition changes. So, people in their 80s and 90s all look the same: their fat is distributed in the center and the abdomen, and they lose a lot of muscle mass.”

“This has become an increasing problem as life expectancy has increased from 45 at the turn of the century to now over 80,” he continued. “Obviously people would like to remain independent and functional as long as possible, but these changes work against them.

“Because this age-related reduction in muscle mass is associated with a decrease in growth hormone secretion, the rationale for the therapy we’re studying is to try and address the problem by boosting the normal secretion of this hormone,” Thorner said.

Human growth hormone, produced naturally by the body’s pituitary gland, is essential to healthy development and the maintenance of tissues and organs. But as people enter their 30s and 40s, levels of the hormone start to decline.

Synthetic versions are legally prescribed for children with “dwarfism” and for adults with a abnormal deficiency – the decline brought about by ageing is not considered abnormal.

Nevertheless, a growing number of adults spend thousands of dollars on buying self-injectable human growth hormone which can be bought on the internet or prescribed by anti-ageing doctors.

Its use is controversial and has also become the focus of “sports doping” headlines, with well-known athletes allegedly turning to the drug for its reputed performance-enhancing properties.

According to the American College of Physicians, it’s estimated that some patients spend as much as $1,000 to $2,000 per month on the drug for anti-aging purposes.

Read more about muscles and ageing the US National Institute on Aging

Purple tomato may fight cancer

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London: British Scientists have developed purple tomatoes which they hope may be able to keep cancer at bay.

The fruit are rich in an antioxidant pigment called anthocyanin which is thought to have anti-cancer properties, according to a study published in Nature Biotechnology.

A team from the John Innes Centre, Norwich, created the tomatoes by incorporating genes from the snapdragon flower, which is high in anthocyanin.

It was discovered that mice who ate the tomatoes lived longer. This discovery offers the potential to promote health through diet by reducing the impact of chronic disease

Anthocyanins, found in particularly high levels in dark coloured berries such as blackberry, cranberry and chokeberry, have been shown to help significantly slow the growth of colon cancer cells.

They are also thought to offer protection against cardiovascular disease and age-related degenerative diseases.

There is also evidence that the pigments have anti-inflammatory properties, help boost eyesight, and may help stave off obesity and diabetes.

Tomatoes already contain high levels of beneficial antioxidant compounds, such as lycopene and flavonoids.

New drug relieves rheumatoid arthritis

San Francisco: A new ‘smart drug’ which halts pain and disability for almost half of rheumatoid arthritis patients could go on sale in months.

The drug, called Tocilizumab, has not yet been licensed in Europe, contains a laboratory-made anti-body that blocks interleukin-6, an immune system messenger involved in the inflammation process of the disease. Drug maker Roche hopes to get a licence for sales next year.

The latest results from a trial carried out in 15 countries are to be presented to the American College of Rheumatology meeting in San Francisco.

It looked at the effects of Tocilizumab prescribed with the standard drug treatment, Methotrexate, compared to Methotrexate alone in 1,190 patients with moderate to severe rheumatoid arthritis.

The combination treatment slowed structural damage of joints in patients with rheumatoid arthritis by 85 per cent, compared with 67 per cent in those on standard treatment.

Researchers found 47 per cent of patients on combination treatment achieved remission – where the disease stops advancing – compared with just eight per cent of those treated with methotrexate alone.

Diet pill Acomplia banned in EU

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London: The controversial diet pill Acomplia has been banned by European safety chiefs, over concerns that it may be linked to suicide in vulnerable individuals.

The European Medicines Agency (EMA) has ordered doctors to stop prescribing Acomplia now following several deaths, including a suicide and reports of other adverse reactions. It is already banned in the US.

The UK’s, National Institute for Health and Clinical Excellence approved the drug four months ago. At that time there were warnings on the packet about the increased risk of depression, anxiety and other ‘serious’ side effects. The EMA also warned that Acomplia should not be taken by patients with major depression or on antidepressants.

Now the EMA has suspended the medicine’s licence because the ‘benefits no longer outweigh its risks’.

It said: “New data from post-marketing experience and ongoing clinical trials indicated that serious psychiatric disorders may be more common than in the clinical trials.”

Patients taking Acomplia are advised to see their doctor or pharmacist

Acomplia, also known as rimonabant, was licensed for the treatment of obesity and overweight patients with type 2 diabetes.

In medical trials. the drug demonstrated that it was helpful to two out five patients in loosing up to 10 per cent of their body body weight.

But a scientific review in The Lancet medical journal found a 40 per cent higher chance of being harmed by ‘adverse events or serious adverse events’.

The pill, made by the French firm Sanofi-Aventis, works by interfering with a system in the body which controls energy levels, reducing the cravings for food and helping to prevent fat from being deposited.

Acomplia costs £44 a month in the UK, and is marketed in 18 European countries.

Don’t talk down to your olders!

New York: “Sweetie”, “Dear” and “What can I do for you today, young lady?” are all phrases that raise the hackles of the otherwise easy-going 83-year-old New Yorker.

“That sort of rhetoric changes me from a “sweet”, “dear” little old lady into a fierce cranky virago,” declared the feisty 5-ft tall retired charity fundraiser, occasional actress and yoga enthusiast.

But the condescending terms that so exasperate Miss Kelly are not just insulting to many elderly people; they can also be bad for their health, according to two ground-breaking studies.

So-called “elderspeak” – defined by researchers as overly caring, controlling and infantilising communication – bears many similar traits to “baby talk”, including simplified grammar and vocabulary and overly intimate endearments.

And such verbal ageism can harm longevity by delivering a self-fulfilling message that older people are incompetent, frail and feeble, sending them into a negative downward spiral, researchers say.

“Elderspeak is indicative of general negative stereotypes of the elderly,” said Becca Levy, a Yale School of Public Health professor. “It is another example of how people are treated differently based on their age in health care, in the workforce and in everyday life. And we have found a clear connection between the how the elderly are treated and their health and functioning.”

In a study that first alerted the academic world to these dangers, she found that older people exposed to negative stereotypes associated with ageing, reinforced by belittling phrases and condescending attitudes, performed markedly worse in memory and balance tests than peers who were not.

Indeed, in one Ohio town, she and her fellow researchers concluded that people aged over 50 who held positive perceptions about ageing lived on average of 7.5 years longer than those who did not, even when other health factors were allowed for. Remarkably, those perceptions – fuelled by even apparently innocuous words and phrases – had a greater impact than exercise or not smoking.

The worst offenders in elderspeak are often health care workers, whether it is doctors telling older patients who question them “You don’t want to upset your family, do you?” or nursing staff who deal with the elderly every day.

Indeed, Kristine Williams, a trained nurse and associate professor at Kansas University, found that nursing home residents with Alzheimer’s who are addressed like children are more likely to resist medical care – with obvious detrimental effects for their health.

Dr Williams and her team filmed the relationship between 20 patients with dementia and nursing staff. When spoken to and treated like children, many pulled faces, yelled or refused to do what they were told or co-operate with care.

Even for older patients receiving medical care for conditions not related to mental health, being spoken to and treated like a child can have a marked impact on their welfare.

“I was in hospital for two months after a fall and the whole time was subjected to condescending treatment and phrases such as “sweetie”, “dear” and “good girl”,” said Elaine Smith, 78, a retired Chicago schoolteacher.

“I often didn’t feel strong enough to answer back. But even worse, I felt that this sort of attitude and message was grinding me down. It reduces your self-esteem and at times I felt it was just easiest to give in to the stereotype that I didn’t know what I wanted or needed.”

Concern about ageism in all its forms, including elderspeak, has grown as the US population greys. The 85-and-over age group is the country’s fastest-growing demographic while Americans turning 65 now will live on average to 83.

Yet, says Dr Robert Butler, president of the International Longevity Centre-USA, that seems to do little to challenge the growth of ageism – the term he first conjured nearly four decades ago. “Daily we are witness to, or even unwitting participants in, cruel imagery, jokes, languages and attitudes directed at older people,” he said.

The current US presidential contest, in which John McCain is hoping to become the oldest candidate to win the presidency for the first time at the age of 72, has also thrust attitudes towards the elderly into the public spotlight.

Late night comics have regularly lampooned him as an angry or doddery old man while the Democratic candidate Barack Obama came under fire from the McCain campaign for allegedly deploying barely-coded language when he remarked that his rival had “lost his bearings”.

As a principle, Miss Kelly now makes clear her objections to patronising forms of address. “I really am a little old lady but there is nothing wrong with my mind and I don’t like being talked down to,” she said.

“When I tell people they have offended me like that, they can be quite indignant and enunciate very slowly that they were just trying to be nice.

“But I believe that the people who heap these endearments upon us are reacting to their own fears of ageing in a youth-oriented culture. My advice, darlings – get over it.”