Scientists reverse brain defects in animal models

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Tel Aviv: Brain birth defects have been successfully reversed, using stem cells, in animal models by scientists at the Hebrew University of Jerusalem.

Neural and behavioral birth defects, such as learning disabilities, are particularly difficult to treat, compared to defects with known cause factors such as ParkinsonĀ’s or AlzheimerĀ’s disease, because the prenatal teratogen Ā– the substances that cause the abnormalities — act diffusely in the fetal brain, resulting in multiple defects.

Prof. Joseph Yanai and his team at the Hebrew university-Hadassah Medical School were able to overcome this obstacle in laboratory tests with mice by using mouse embryonic neural stem cells. These cells migrate in the brain, search for the deficiency that caused the defect, and then differentiate into becoming the cells needed to repair the damage.

The stem cells may develop into any type of cell in the body, however at a certain point they begin to commit to a general function, such as neural stem cells, destined to play a role in the brain/ nervous system. At more advanced developmental stages, the neural stem cells take on an even more specific role as neural or glial (supporting) cells within the brain/ nervous system.

In the researchersĀ’ animal model, they were able to reverse learning deficits in the offspring of pregnant mice who were exposed to organophosphate (a pesticide) and heroin. This was done by direct neural stem cell transplantation into the brains of the offspring. The recovery was almost one hundred percent, as proved in behavioral tests in which the treated animals improved to normal behavior and learning scores after the transplantation. On the molecular level, brain chemistry of the treated animals was also restored to normal.

The researchers went one step further. Puzzled by the stem cellsĀ’ ability to work even in those cases where most of them died out in the host brain, the scientists went on to discover that the neural stem cells succeed before they die in inducing the host brain itself to produce large number of stem cells which repair the damage. This discovery, finally settling a major question in stem cell research, evoked great interest and was published earlier this year in one of the leading journals in the field, Molecular Psychiatry.

The scientists are now in the midst of developing procedures for the least invasive method for administering the neural stem cells, which is probably via blood vessels, thus making the therapy practical and clinically feasible.

Normally, stem cells are derived from individuals genetically different from the patient to be transplanted, and therefore the efficacy of the treatment suffers from immunological rejection. For this reason, another important avenue of the ongoing study, toward the same goals, will be to eliminate the immunological rejection of the transplant, which will become possible by taking cells from the patientĀ’s own body — from a place where they are easily obtained — by manipulating them to return to their stem cell phase of development, and then transplanting them into the patientĀ’s brain via the blood stream. One important advantage of this approach will be to eliminate the controversial ethical issues involved in the use of embryo stem cells.

The research on the project has been supported by the US National Institutes of Health, the US-Israel Binational Science Foundation and the Israel anti-drug authorities.

Cellular Therapy

Cellular therapy – also known as live cell therapy, cellular suspensions, glandular therapy, fresh cell therapy, embryonic therapy, refers to certain treatments in which the processed tissue from animal embryos, foetuses or organis, is injected or taken orally.

The theory is that the material from the organs correspondents with the ailing or diseased organ. The animals cells work by regenerating the unhealthy organ.

The organs and glands used include thymus, liver, kidney, pancreas, spleen, heart, ovary, testis, brain, pituitary and thyroid. They can be given individually or in combination.

The Swiss physician Paul Niehans (1882-1971) is known as “the father of cell therapy”. He founded the famous Clinique La Prairie in Clarens-Montreaux in Switzerland.

There are other clinics, mostly in Europe, offering this therapy in various forms.
There are several variations of cell therapy: the actual organic matter used can be frozen, freeze-dried or suspended in a serum. It can also be taken orally or injected intramuscularly. The cells are usually taken from the embryos of sheep or lambs.

The US company Cell Life Forever, for example, offers oral live cell therapy for the brain, prostate, muscle, skin, testical, kidney, heart, liver, bone marrow and placenta, amongst others.

The company sources its product in France and says that it is checked by the French government’s Institute Alfred Fournier laboratory.

Cell Life Forever says: “Some people may feel or see changes immediately, while others may take a number of supplements and not see any changes. “

The company says that it is unique in providing live cells. In Germany for example, Opotherapy treatments use products altered by sterilisation.

www.celllifeforever.com

The Baxamed Clinic (Basel, Switzerland) offers “biomodular cell therapy”, which it says can be used as a preventative measure against ageing and also in the the treatment of various diseases.

The fetal cells are sourced from bovine and sheep organs from controlled herds in Australia and New Zealand.

Diseases that can be treated by biomodular cell therapy include congestive heart disease, sexual impotence, Parkinson’s disease, stroke, chronic fatigue, many auto-immune diseases and Down Syndrome. The treatment is customized to each patients’ needs. The products are injected intramuscularly, usually without any negative reaction.

RNA Products

RNA products are made exclusively of biologically active Ribonucleic Acids from fetal organs. These are essential components ov every single cell in the body. They are responsible for carrying out the instructions embedded in the nucleus of the cell for the growth and maintenance of the cell. During the time of youth there is an abundant supply of RNA to ensure the cells health. After the age of 40, though the amount of RNA in each cell dwindles as time passes and chronic degenerative diseases based on a malfunctioning cell repair system start to occur. These products supply the cells with the missing RNA. They come in single organ preparations and in combination products. For a general revitalisation, the RN 13 is commonly used. RN 13, as the name says, contains the RNA of 13 different organ systems. The main strength of RNA though is the successfull treatment of many degenerative diseases, such as Parkinson’s, MS, Post Polio Syndrome and others. The effect of RNA treatment comes on over an extended period of time. Depending on the site and severity of the disease, the effects are usually noticeable within 1 to 3 weeks, In severe cases, the treatment should be repeated every 1 to 2 years.

Thymus Therapy

The Thymus product we use contains 50 mg Thymus Extract with standardized polypeptides including Thymosin. It is used in the treatment of:
Impaired Immune Function
Old Age
Opportunistic Infections
Chronic Infections
Rheumatoid Diseases
Support of Cancer treatments
Prevention of Allergies

The most important system in the human body is the immune system. it is responsible for fighting off infective agents such as bacteria and viruses. More important though is its neuroendocrine ability. Research has shown that there is an important link between Thymus hormones and other hormones in the entire body. Thymus hormones induce other glands to produce their specific hormones. In addition, a healthy immune system is of the essence to prevent autoimmune diseases from developing. Thymosin is used not only in the treatment of disease, but also as a preventive measure. The usual course of treatment involves 10 intramuscular injections given over a period of 3 weeks.

The Center for Holistic Life Extension, San Ysidro, California

482 W. san Ysidro Blvd, Suite 1365, San Ysidro, California 92173
TL 01152 664 624 9639

This clinic uses embryonic cells from the blue shark to treat patients.

Health Center Clinique Lemana, Switzerland

Royal Plaza, Grand Rue 97 Case Postale 347
CH-1815 Clarens-Montreaux
T: +41 021 961 38 12
F: +41 021 961 3813
email: admin@lemana.com

This clinic uses Cellvital therapy