British scientists behind new wrinkle-buster that reverses skin ageing

British scientists are behind an antioxidant so powerful that it reverses skin ageing, reducing fine lines and wrinkles in only a few weeks.Capture-d'écran-2012-07-17-à-15.44.24-230x260.png

MitoQ, the name of the antioxidant and also the name of a new anti-ageing cream containing it, goes on sale next month with the promise of benefits not seen to date in any other anti-wrinkle product.
Firstly, the antioxidant is 1,000 times more powerful than any other on the market and secondly, the makers claim, it’s the only one capable of penetrating deep enough into the skin to make a significant difference to wrinkles. And the claims are not hype – they have been validated by a Nobel Laureate Prize to the Cambridge scientist behind it and in prestigious scientific journals.
MitoQ has been scientifically engineered from the antioxidant CoQ10, found naturally in foods such as sardines, and essential to a healthy heart and brain.  But what makes it so potent, as well as its strength, is it’s ability to pass through the outer layer of the mitochondria (these are the energy powerhouses inside every living cell) and where the MitoQ is used as fuel. The mitochondria are subsequently able to function more efficiently as a result.
This means that as the mitochondria are working at optimum function, and the cells in the skin that they energise become younger and refreshed,  fine lines and wrinkles diminish.
The success of MitoQ is now behind a new generation of ground-breaking anti-ageing products being brought to market, including an anti-ageing pill due to go on sale next year. The product pipeline is being developed in New Zealand.
The science behind MitoQ, pioneered by a team led by Dr Michael Murphy, at the Cambridge-based Mitochodrial Dysfunction Laboratory, has been recognised by a Nobel Laureate.  The team found a way to engineer the antioxidant to pass through the mitochondria.
MitoQ promises a real improvement for ageing skin where damage is accelerated by the sun, smoking and a poor lifestyle. The quality of the skin cells deteriorates and they are less able to fight off further damage from free radicals – these are the damaging byproducts of the living process.  When the cells replicate they do so less efficiently resulting in fine lines and other signs of ageing.
When MitoQ is topically applied to the skin, it passes through to the mitochondria, which are re-energised, giving the skin cells better quality fuel, so that they are rejuvenated and able to lay down better quality collagen – thereby making the skin younger.
The claims for MitoQ have been verified by independent sources including Professor John Voorhees MD, former President of the American Academy of Dermatology and Director of the Division of Dermatology at the University of Michigan, who confirms that MitoQ repairs internal and external damage caused by the sun, including pigmentation spots.
And in clinical trials in New Zealand, 50 patients who used the cream for 2 weeks, reported lightening and brightening of skin, as well as the diminishing of fine lines and wrinkles. To see the full benefits MitoQ should be used over the entire skin renewal cycle which is about four weeks and continue with use thereafter.  
At the current time, the only other ‘power’ antioxdant being used in anti-wrinkle creams is idebenone which is an ingredient in Prevage by Elizabeth Arden (£105, 30ml) – MitoQ is 1,000 times more powerful.
Manufacturer, MitoQ Ltd, is backed by New Zealand and US investors, has decided to launch their product without hype – ie no celebrity face or endorsement and with their miracle ingredient in a base cream generally used for babies bottoms.
Ken Taylor, CEO explains:  “We want the science to speak for itself.  And we also wanted to bring the product to the market and make it as affordable as possible. Putting it in an aqueous cream base without any irritants means that it can easily be used with any other product without a problem.”
What Elixir says about this product:
“We don’t endorse any product but we have managed to obtain an early sample. The tester who has been using it for three weeks confirms a reduction in fine lines and wrinkles. In particular, a real improvement to the skin quality on the upper eyelid and the neck area where the pores have become more refined.”
A full product review will follow on
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Idebenone is a man-made antioxidant, similar to Co Q10, which was originally used to preserve transplant organs. It is widely used in topical anti-wrinkle creams.

Idebenone Fights Photoaging, Improves Skin Health

As adults age, their skin is more likely to exhibit the effects of photoaging, which produces negative changes in skin color, texture, and health caused by cumulative exposure to ultraviolet light. New findings suggest that antioxidant-rich, high-energy compounds may help defend against the effects of photoaging.

Free radicals damage not only proteins and DNA, but also the skin’s surface lipids. Made up of a complex mixture of sebum (an oily substance produced by the sebaceous glands) and small amounts of epidermal lipids, these surface lipids provide the body’s outermost protection against oxidative damage.

Coenzyme Q10 (CoQ10) is a fat-soluble antioxidant that helps prevent free-radical damage to the skin’s surface lipids. However, CoQ10 concentrations in skin decline significantly in older people.9 The loss of this protective nutrient is a likely cause of the increased incidences of skin diseases and photoaging seen in aging adults.

In fact, an eight-year Italian study found a direct link between CoQ10 levels and the progression of melanoma, the deadliest of skin cancers.Not only were CoQ10 concentrations in people with melanoma lower than in healthy subjects, but patients whose cancer spread (metastasized) to other tissues had CoQ10 levels below those of the metastasis-free subgroup. Clearly, CoQ10 is an important protective nutrient for aging skin.

Recognizing the importance of CoQ10 in skin health, scientists searched for related compounds that can confer even greater benefits to the skin. This search led to idebenone, a nutritional cousin, or analogue, of CoQ10. Since idebenone is a smaller molecule than CoQ10, it is better suited to penetrating the skin, where it can confer important protective effects.

Idebenone has been shown to produce clinically visible improvements in photodamaged skin. In a study of 41 female subjects aged 30-65, applying idebenone to the face in the morning and evening for six weeks reduced skin roughness and dryness by 26%, and decreased fine lines and wrinkles by 29%.The subjects also exhibited a 37% increase in skin hydration and a 33% overall improvement in assessment for photodamaged skin. These improvements were primarily seen in the epidermis, though there was some increase in dermal collagen as well. Skin biopsies revealed decreased levels of an inflammatory protein, a change associated with the stimulation of collagen production. Topically applied idebenone thus improves numerous markers of skin health while reducing the visible signs of aging.

Idebenone may protect the skin through its potent antioxidant effects.One research team studied various antioxidants to gauge their protective effects against oxidative stress. They found that idebenone was the most effective antioxidant studied, providing more protection than CoQ10, vitamin E, kinetin, vitamin C, or lipoic acid.This antioxidant quality allows idebenone to inhibit lipid peroxidation, thus protecting skin cell lipids and membranes.

Topical use of idebenone represents an important step forward in scientifically based skin care. Through its antioxidant effects, idebenone helps protect skin from the effects of oxidative stress and photoaging, restoring moisture, refining texture, reducing fine lines and wrinkles, and promoting a more youthful appearance.