Advancing age causes a significantly decreased resting metabolic rate.This can lead to age-related increases in body fat along with increased risk of heart disease, diabetes, and dementia. Ageing individuals often find themselves overweight or obese which means a reduced life expectancy.
Dieting can trigger a further meta- bolic slowdown. In several studies, scientists have found that replenishing the levels of a DHEA metabolite known as 7-Keto reverses the age-related decrease in metabolic rate in just 7 days.This translates into reductions in weight and body mass index in just 8 weeks!
How 7-Keto Works
Scientists are beginning to uncover the mechanisms of action behind the remarkable ability of 7-Keto to reverse the age-related decrease in resting metabolic rate and to produce various anti- ageing benefits.
Scientific studies indicate that 7-Keto power- fully boosts levels of three liver enzymes that result in stimulation of fatty acid oxidation:
- Glycerol-3-phosphate dehydrogenase
- Malic enzyme
- Fatty acyl CoA oxidase
These enzymes accelerate a heat-generating process called thermogenesis, which promotes the burning of fat reserves. Because this thermo-genic effect reverses the age-related decrease in resting metabolic rate, this may explain 7-Keto’s ability to decrease weight and body fat.
Supplementing with 7-Keto results in elevated levels of the T-3 thyroid hormone. Thyroid hormones regulate metabolic activity, which declines with age.This explains another potential mechanism by which 7-Keto triggers reductions in body weight and body fat.
7-Keto has been shown to enhance the production of interleukin-2 in human lymphocytes.When interleukin-2 reacts with its corresponding receptor sites on cell surfaces, it stimulates production and differentiation of various T-lymphocytes, which in turn trigger production of other immune agents.
The result is a broad enhancement of the immune system, which is normally weakened by advancing age.
Study participants experienced decreased immune suppressor cells and increased immune helper cells.Supplementation with 7-Keto may fortify defenses against numerous conditions, including killers such as cancer and AIDS.
DHEA versus 7-Keto
DHEA is the body’s most abundant hormone, but its production peaks in the 20s and steadily declines, leading to age-related hormonal imbalances.
DHEA is converted by the body into androstenedione, which is then converted into the male and female sex steroid hormones, estrogen and testosterone. This conversion is highly individualised and some people could end up with excess levels of these sex hormones–which could pose a risk if any of those individuals have a hormone-dependent disease, such as prostate or breast cancer.
Unlike DHEA however, 7-Keto does not trigger higher sex hormone levels.That means that supple- menting with 7-Keto may be a safer way for some peo- ple to benefit from these anti-aging effects including enhancing the immune system, reducing age-related memory loss, and improving cholesterol profiles.
Colker CM, Torina GC, Swain MA, Kalman DS. Double-Blind Study Evaluating the Effects of Exercise Plus 3-Acetyl-7-oxo-dehydroepiandrosterone on Body Composition and the Endocrine System in Overweight Adults. Abstract presented at 2nd ASEP Annual Meeting, October 14-16, 1999, and published in Journal of Exercise Physiology online, Volume 2 Number 4 October 1999.